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17 years
My cousin is Infected with Hodgkin. on her 5th session (once/2 weeks) z hosptial told us that they gave her bymistake an overdose of dacarbazine. What are the risks and damage that may occur with it?
Jun 3, 2013

Dr. Rania Mousa General Medicine
As long as your cousin is in hospital special serious emergency care must be taken and frequent monitoring should be done ,what are risks depends on the overdose taken and the body reaction,since she is in hospital then they will do the necessary and special care for any possible effect will be done the risks will minimize and the patient will be watched on eye and monitored The primary anticipated complications of overdose are severe bone marrow suppression,
eventually bone marrow aplasia which may be delayed by up to two weeks.
Time to occurrence of nadirs of leucocytes and thrombocytes can be 4 weeks. Even if overdosage is only suspected, long-term careful hematologic monitoring is essential. There is no known antidote for dacarbazine overdose.Therefore, special care has to be taken to avoid overdose of this drug
Symptoms of a dacarbazine overdose include the side effects but are usually of a more severe nature.
general side effects of decarbazine:
-nausea, vomiting and loss of appetite
-skin rash or itching
-lethargy (tiredness)
-signs of infection, such as fever, chills, sore throat or mouth ulcers
-pain or irritation at the injection site
-symptoms of an allergic reaction, such as those listed at the start of this -leaflet
-severe abdominal pain
-unusual bleeding or bruising (including blood in your stools or urine)
-problems with urination ex pain or difficulty
-dizziness upon standing (due to a fall in blood pressure)
-tingling, tremors or pain in your muscles
-blurred vision
-yellowing of the skin or eyeballs
-severe nausea and vomiting
-fits (seizures)