eventually bone marrow aplasia which may be delayed by up to two weeks.
Time to occurrence of nadirs of leucocytes and thrombocytes can be 4 weeks. Even if overdosage is only suspected, long-term careful hematologic monitoring is essential. There is no known antidote for dacarbazine overdose.Therefore, special care has to be taken to avoid overdose of this drug
Symptoms of a dacarbazine overdose include the side effects but are usually of a more severe nature.
general side effects of decarbazine:
-nausea, vomiting and loss of appetite
-skin rash or itching
-signs of infection, such as fever, chills, sore throat or mouth ulcers
-pain or irritation at the injection site
-symptoms of an allergic reaction, such as those listed at the start of this -leaflet
-severe abdominal pain
-unusual bleeding or bruising (including blood in your stools or urine)
-problems with urination ex pain or difficulty
-dizziness upon standing (due to a fall in blood pressure)
-tingling, tremors or pain in your muscles
-yellowing of the skin or eyeballs
-severe nausea and vomiting